منابع مشابه
Human Protein Z.
Protein Z was purified from human plasma by a four-step procedure which included barium citrate adsorption, ammonium sulfate fractionation, DEAE-Sepharose chromatography, and blue agarose chromatography with a yield of 20%. It is a 62,000 mol wt protein with an extinction coefficient of 12.0. The concentration of Protein Z in pooled, citrated plasma is 2.2 micrograms/ml and its half-life in pat...
متن کاملHuman endothelial cells synthesize protein Z, but not the protein Z dependent inhibitor.
Protein Z (PZ) is a vitamin K-dependent protein isolated from human plasma, and acts as a cofactor for a serpin, called protein Z-dependent protease inhibitor (ZPI). A prothrombotic phenotype has been reported in PZ deficient mice, and PZ deficiencies have been observed in patients with arterial thrombotic events. PZ was immunologically detected in the endothelium of atherosclerotic arteries, s...
متن کاملProtein Z gene polymorphisms, protein Z concentrations, and ischemic stroke.
BACKGROUND AND PURPOSE We aimed to determine whether A-13G or G79A polymorphisms of the protein Z gene that have been reported to be an important determinant of blood concentrations of protein Z are associated with risk of ischemic stroke in a broad range of stroke patients and controls. METHODS We conducted a case control study of 151 hospital cases of first-ever ischemic stroke and 164 rand...
متن کاملThe protein Z/protein Z-dependent protease inhibitor complex.
Protein Z (PZ) is a vitamin K-dependent factor identified in human plasma in 1984 but it has no enzymatic activity. It is a cofactor of a serpin, the protein Z-dependent protease inhibitor (ZPI), and the complex PZ/ZPI inhibits activated factor X on phospholipid surfaces. In mice, the disruption of PZ or ZPI gene is asymptomatic, but enhances the thrombotic phenotype and mortality of other thro...
متن کاملProtein Z levels, protein Z G79A polymorphism, and prothrombotic conditions.
Protein Z Levels, Protein Z G79A Polymorphism, and Prothrombotic Conditions To the Editor: We read with great interest the article on protein Z gene polymorphisms, protein Z concentrations, and ischemic stroke published by Staton et al.1 The authors examine protein Z concentrations and 2 common polymorphisms of the protein Z gene in patients with a first-ever ischemic stroke and conclude that h...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1984
ISSN: 0021-9738
DOI: 10.1172/jci111317